Regenerative medicine may be defined as the process of replacing or “regenerating” human cells, tissues or organs to restore or establish normal function. Commonly you may hear the word “Stem-Cell” and it’s often surrounded by controversy. “Stem-Cells” were only the beginning and there are now a multitude of innovative human tissue products being studied and available that may be more than helpful for cellular regeneration, pain, Inflammation, anti-aging and more.
Whether you’re an athlete, have jobs that require physical labor or simply have years of wear and tear on your joints, joint pain can be very painful and uncomfortable to live with. Luckily, there are many different treatments available today to help relieve joint pain symptoms, such as Transcutaneous electrical nerve stimulator (TENS) machines, supplements like glucosamine and chondroitin, and more. Some researchers are even interested in the potential of something called exosomes as a way to help relieve joint pain symptoms in the future, but what exactly are they?
What are exosomes?
Exosomes are small, membrane-bound vesicles that contain proteins, lipids, RNA, and DNA. They are naturally released from cells in a process called exocytosis. These exosomes then travel to other nearby cells. It is now believed that exosomes play a role in cellular communication by transporting information between cells.
There has been extensive research on exosomes in recent years as scientists have begun to see these tiny vesicles as important players in human health. Studies have shown that when healthy synovial fluid is introduced into a cell culture of inflammatory cells, there will be an inhibition of cytokine production. So it would seem that synovial fluid contains something in the form of exosomes which inhibits inflammation in neighboring cells. What exactly this something is remains unknown but researchers think it could be enzymes or growth factors contained within exosomes which inhibit cytokines (inflammatory molecules).
The study also showed that when synovial fluid was mixed with osteoarthritis serum (serum with proinflammatory molecules), there was an increase in cytokine production. The increase seemed to indicate an inflammatory response triggered by contact with osteoarthritis serum and not because of any substances contained within the synovial fluid itself.
How do exosomes affect joint pain?
The exosomes are small protein-lipid vesicles that are secreted by cells. They can be found in many different body fluids, including blood, saliva, or urine. Exosomes appear to help cells communicate with each other and carry messages from one cell to another. It is not yet known how these tiny particles affect joint pain, but it may have to do with their ability to regulate immune responses in joints.
Research has shown that injecting exosomes into a mouse model of rheumatoid arthritis can reduce inflammatory responses in the animals. Exosomes also seem to protect against pro-inflammatory cytokines like TNF alpha (Tumour Necrosis Factor alpha). These findings are promising for those living with joint pain.
Exosomes also seem to play a role in other diseases that affect joints, like osteoarthritis. Here too, researchers are still working to figure out how they work. Since exosomes are involved in cell signalling, they could be a good target for drugs used to treat bone health problems like osteoporosis. In fact, some research has shown that exercise leads to an increase in both exosomal proteins and proteins involved in inflammation signaling pathways after exercise—suggesting there may be a link between these factors. More research is needed before any conclusions can be drawn about a potential relationship between exosomes and joint pain.
What are the benefits of exosome therapy?
There are a number of benefits of exosome therapy, including the following.
– The therapy can reduce inflammation in the joints. This can help to alleviate or eliminate the symptoms of arthritis and other inflammatory diseases.
– Therapy may help to stimulate healing in the cells, making it possible for people to recover from injury or disease much faster than they would otherwise be able to do.
– Treatment has been shown to heal bone fractures, which will make it more likely that a person who breaks his or her leg will be able to walk normally again without experiencing any lingering effects of the injury later on in life.
– One of the most promising areas where this type of therapy might be useful is in cancer treatment. Doctors have been researching whether it might work as an effective form of immunotherapy. It could potentially stop tumors from growing by blocking cell signals and communicating with white blood cells so that they attack cancerous cells instead.
– Exosomes may also one day provide a way to correct genetic mutations associated with disorders like Alzheimer’s disease, Parkinson’s disease, schizophrenia, or depression.
Can exosome therapy help you?
If you’re suffering from joint pain, exosome therapy may be able to help. As stated previously the therapy delivers exosomes, which are tiny particles that act as cell messengers and can protect joints by reducing inflammation in the synovial membrane. If you have been experiencing joint pain, exosome therapy in Fort Lauderdale, FL at The Remedy Health + Wellness may be an option for you.
Content Writer: John Annunziata / The Remedy Health + Wellness
